Synthesis, antibacterial studies, and molecular modeling studies of 3,4-dihydropyrimidinone compounds

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Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl2 as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.

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ژورنال

عنوان ژورنال: Journal of Chemical Biology

سال: 2015

ISSN: 1864-6158,1864-6166

DOI: 10.1007/s12154-015-0142-4